- Alcina Lubitch Domecq, author
- Alfonso Portillo Cabrera, former president
- Álvaro Colom Caballeros, politician
- Anton Villatoro professional cyclist
- Augusto Monterroso, winner of the Prince of Asturias Award of literature (2000)
- Benito Martinez , actor
- Carlos Castillo Armas, former president
- Carlos Ruiz, FC Dallas soccer player
- Daphne Zuniga, Guatemalan-American actress
- David Estrada, Guatemalan-Mexican boxer
- David Unger, author
- Deborah David, fashion model
- Edmond Mulet, UN Diplomat
- Eduardo Stein, Guatemalan vice-president under Oscar Berger
- Efraín Ríos Montt, retired general, politician, former dictator
- Federico Urruela, Diplomat
- Fernando Quevedo, Professor of Theoretical Physics, Cambridge
- Fernando Romeo Lucas García, former dictator
- Francisco Goldman, author, half Guatemalan half American
- Harris Whitbeck, CNN correspondent
- Héctor Fernando Ramírez
- Héctor Sandarti, television personality
- Hector Tobar, writer/journalist
- Ilma Julieta Urrutia Chang, Miss International 1984
- Irma Flaquer, journalist (assassinated)
- Jacobo Arbenz, former president
- Jaime Permuth, photographer
- Jaime Viñals, mountaineer
- Jorge Ubico, former dictator
- Jose Milla y Vidaurre (Salome Jil), writer
- José Rubén Zamora, journalist
- Juan José Arévalo, former president
- Justo Rufino Barrios, former dictator
- KC Porter, multiple Grammy winning producer
- Kevin Sandoval, Guatemalan soccer player, 1988 Summer Olympics
- Luis Argueta, film director
- Luis Cardoza y Aragón, writer
- Luis González Palma, photographer
- Manny Marroquin, Grammy Award winning mixer/engineer
- Manuel Estrada Cabrera, former dictator
- Mario Monteforte Toledo, author
- Miguel Ángel Asturias, winner of the Nobel Prize in literature (1967).
- Miroslava, vocalist trainer living in Europe
- Myrna Mack, political activist (assassinated)
- Oscar Isaac, Guatemalan-American actor
- Rafael Carrera, former dictator
- Ricardo Arjona, internationally acclaimed singer incorporating political and social satire
- Ricardo Arnoldo Ramirez de León, leftist guerrilla leader (Guerrilla Army of the Poor), a.k.a. Rolando Morán.
- Rigoberta Menchú Tum, winner of the Nobel Peace Prize (1992)
- Rodolfo Abularach, painter
- Rogelia Cruz Martínez, Miss Universe Contestant, JPT Member, 1968 Murder Victim
- Sabrina, Guatemalan singer
- Ted Hendricks, American football linebacker
- Tom Weihmayr, political activist
- Zury Ríos Sosa, congresswoman